Drug interactions
Brexpiprazole + Oliceridine
Severity: Major
Brexpiprazole and Oliceridine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oliceridine is an intravenous opioid and brexpiprazole is a sedating antipsychotic, so together they can cause profound sedation, hypotension and respiratory depression. Opioid labeling warns of this with other CNS depressants.
What this interaction means in plain words
Brexpiprazole and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Brexpiprazole belongs to Central Nervous System; Oliceridine belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression from opioid agonism and antipsychotic sedative effects.
What to do
Use the lowest effective oliceridine dose and shortest duration, and monitor sedation, respiratory rate and oxygen saturation. Reduce doses if excessive sedation occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Brexpiprazole
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Brexpiprazole with Oliceridine?
MediHelp rates the interaction as major. Brexpiprazole and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oliceridine is an intravenous opioid and brexpiprazole is a sedating antipsychotic, so together they can cause profound sedation, hypotension and respiratory depression. Opioid labeling warns of this with other CNS depressants.
How serious is the interaction between Brexpiprazole and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective oliceridine dose and shortest duration, and monitor sedation, respiratory rate and oxygen saturation. Reduce doses if excessive sedation occurs.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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