Drug interactions
Brexpiprazole + Oxymorphone
Severity: Moderate
Brexpiprazole and Oxymorphone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an opioid with an antipsychotic such as brexpiprazole can produce additive sedation, dizziness and orthostatic hypotension. Respiratory depression is possible, particularly with higher opioid doses or in vulnerable patients.
What this interaction means in plain words
Brexpiprazole and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Oxymorphone belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression and alpha-adrenergic related hypotension.
What to do
Start with the lowest effective doses and titrate slowly. Monitor for excessive sedation, respiratory depression and hypotension, and counsel patients about driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Oxymorphone?
MediHelp rates the interaction as moderate. Brexpiprazole and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an opioid with an antipsychotic such as brexpiprazole can produce additive sedation, dizziness and orthostatic hypotension. Respiratory depression is possible, particularly with higher opioid doses or in vulnerable patients.
How serious is the interaction between Brexpiprazole and Oxymorphone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest effective doses and titrate slowly. Monitor for excessive sedation, respiratory depression and hypotension, and counsel patients about driving and alcohol.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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