Drug interactions
Brexpiprazole + Sertraline
Severity: Moderate
Brexpiprazole and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexpiprazole is cleared by CYP2D6 and CYP3A4, and sertraline is a mild to moderate CYP2D6 inhibitor at higher doses, which may raise brexpiprazole levels. The effect is greater if a CYP3A4 inhibitor is also given.
What this interaction means in plain words
Brexpiprazole and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Sertraline belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6 (and weakly CYP3A4) by sertraline decreasing brexpiprazole clearance.
What to do
Monitor for akathisia, sedation and other adverse effects and reduce the brexpiprazole dose if they occur. Follow labeling dose reductions if combined with both a CYP2D6 and a CYP3A4 inhibitor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Sertraline?
MediHelp rates the interaction as moderate. Brexpiprazole and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brexpiprazole is cleared by CYP2D6 and CYP3A4, and sertraline is a mild to moderate CYP2D6 inhibitor at higher doses, which may raise brexpiprazole levels. The effect is greater if a CYP3A4 inhibitor is also given.
How serious is the interaction between Brexpiprazole and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for akathisia, sedation and other adverse effects and reduce the brexpiprazole dose if they occur. Follow labeling dose reductions if combined with both a CYP2D6 and a CYP3A4 inhibitor.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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