Drug interactions
Brexpiprazole + Terbinafine
Severity: Moderate
Brexpiprazole and Terbinafine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Terbinafine inhibits CYP2D6, one of the main enzymes clearing brexpiprazole, and can raise its exposure. This may increase adverse effects such as akathisia, somnolence and weight gain.
What this interaction means in plain words
Brexpiprazole and Terbinafine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Terbinafine belongs to Anti Fungals.
Why it happens
CYP2D6 inhibition by terbinafine reduces brexpiprazole clearance.
What to do
Reduce the brexpiprazole dose as per labeling for strong CYP2D6 inhibitors (about half) and monitor tolerability; return to the usual dose after terbinafine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Terbinafine?
MediHelp rates the interaction as moderate. Brexpiprazole and Terbinafine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Terbinafine inhibits CYP2D6, one of the main enzymes clearing brexpiprazole, and can raise its exposure. This may increase adverse effects such as akathisia, somnolence and weight gain.
How serious is the interaction between Brexpiprazole and Terbinafine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the brexpiprazole dose as per labeling for strong CYP2D6 inhibitors (about half) and monitor tolerability; return to the usual dose after terbinafine is stopped.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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