Drug interactions
Brexpiprazole + Tetrabenazine
Severity: Moderate
Brexpiprazole and Tetrabenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation, and both affect dopaminergic signalling, so combining them may increase somnolence, parkinsonism, akathisia and the risk of neuroleptic malignant syndrome. Tetrabenazine also carries depression and QT concerns that matter in psychiatric patients.
What this interaction means in plain words
Brexpiprazole and Tetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Tetrabenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression and dopamine antagonism (D2 partial agonism with VMAT2 inhibition-mediated dopamine depletion).
What to do
Monitor for sedation, extrapyramidal symptoms, mood changes and ECG changes if clinically indicated. Reduce doses if movement or sedative adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Brexpiprazole and Tetrabenazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Brexpiprazole
Other interactions of Tetrabenazine
- Dronedarone + Tetrabenazine Contraindicated
- Isocarboxazid + Tetrabenazine Contraindicated
- Linezolid + Tetrabenazine Contraindicated
- Phenelzine + Tetrabenazine Contraindicated
- Pimozide + Tetrabenazine Contraindicated
- Procarbazine + Tetrabenazine Contraindicated
Frequently asked questions
Can I take Brexpiprazole with Tetrabenazine?
MediHelp rates the interaction as moderate. Brexpiprazole and Tetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation, and both affect dopaminergic signalling, so combining them may increase somnolence, parkinsonism, akathisia and the risk of neuroleptic malignant syndrome. Tetrabenazine also carries depression and QT concerns that matter in psychiatric patients.
How serious is the interaction between Brexpiprazole and Tetrabenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, extrapyramidal symptoms, mood changes and ECG changes if clinically indicated. Reduce doses if movement or sedative adverse effects emerge.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
