Drug interactions
Brexpiprazole + Thioridazine
Severity: Major
Brexpiprazole and Thioridazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thioridazine inhibits CYP2D6 and may raise brexpiprazole exposure, while both drugs add to sedation. Thioridazine also carries a marked QT risk.
What this interaction means in plain words
Brexpiprazole and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Brexpiprazole belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by thioridazine reduces brexpiprazole clearance, with additive CNS depression and QT effects.
What to do
Avoid combining if possible; if needed, reduce the brexpiprazole dose per labeling for CYP2D6 inhibitors and monitor ECG, sedation and adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Thioridazine?
MediHelp rates the interaction as major. Brexpiprazole and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Thioridazine inhibits CYP2D6 and may raise brexpiprazole exposure, while both drugs add to sedation. Thioridazine also carries a marked QT risk.
How serious is the interaction between Brexpiprazole and Thioridazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining if possible; if needed, reduce the brexpiprazole dose per labeling for CYP2D6 inhibitors and monitor ECG, sedation and adverse effects.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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