Drug interactions
Brexpiprazole + Ticagrelor
Severity: Minor
Brexpiprazole and Ticagrelor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticagrelor is a weak CYP3A4 inhibitor and is unlikely to raise brexpiprazole exposure meaningfully. A dose reduction is only relevant when potent or multiple inhibitors are combined.
What this interaction means in plain words
Brexpiprazole and Ticagrelor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brexpiprazole belongs to Central Nervous System; Ticagrelor belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP3A4-mediated brexpiprazole metabolism by ticagrelor.
What to do
No dose adjustment is normally needed. Monitor for brexpiprazole adverse effects if other CYP2D6 or CYP3A4 inhibitors are also used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Ticagrelor?
MediHelp rates the interaction as minor. Brexpiprazole and Ticagrelor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ticagrelor is a weak CYP3A4 inhibitor and is unlikely to raise brexpiprazole exposure meaningfully. A dose reduction is only relevant when potent or multiple inhibitors are combined.
How serious is the interaction between Brexpiprazole and Ticagrelor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is normally needed. Monitor for brexpiprazole adverse effects if other CYP2D6 or CYP3A4 inhibitors are also used.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
Full monographs, dosing and an interaction checker in the MediHelp app
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