Drug interactions
Brexpiprazole + Tranylcypromine
Severity: Moderate
Brexpiprazole and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tranylcypromine may modestly inhibit CYP2D6 and raise brexpiprazole concentrations, increasing adverse effects such as akathisia, sedation and orthostasis. Both agents also act on monoaminergic systems and may affect blood pressure.
What this interaction means in plain words
Brexpiprazole and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Why it happens
Possible CYP2D6 inhibition by tranylcypromine reducing brexpiprazole clearance, plus additive monoaminergic pharmacodynamic effects.
What to do
Monitor for brexpiprazole adverse effects and blood pressure, and reduce the dose if tolerability is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Tranylcypromine?
MediHelp rates the interaction as moderate. Brexpiprazole and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tranylcypromine may modestly inhibit CYP2D6 and raise brexpiprazole concentrations, increasing adverse effects such as akathisia, sedation and orthostasis. Both agents also act on monoaminergic systems and may affect blood pressure.
How serious is the interaction between Brexpiprazole and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for brexpiprazole adverse effects and blood pressure, and reduce the dose if tolerability is poor.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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