Drug interactions
Brexpiprazole + Valproic acid
Severity: Moderate
Brexpiprazole and Valproic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valproic acid and brexpiprazole both cause sedation and dizziness, so the combination may increase drowsiness. Valproate may also contribute to weight gain and metabolic effects alongside the antipsychotic.
What this interaction means in plain words
Brexpiprazole and Valproic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Valproic acid belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects; no significant pharmacokinetic interaction is expected.
What to do
Monitor for sedation and metabolic changes such as weight, glucose and lipids. Counsel patients about driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Valproic acid
- Ertapenem + Valproic acid Contraindicated
- Imipenem / cilastatin / relebactam + Valproic acid Contraindicated
- Imipenem / cilastatin + Valproic acid Contraindicated
- Meropenem / vaborbactam + Valproic acid Contraindicated
- Meropenem + Valproic acid Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Major
Frequently asked questions
Can I take Brexpiprazole with Valproic acid?
MediHelp rates the interaction as moderate. Brexpiprazole and Valproic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valproic acid and brexpiprazole both cause sedation and dizziness, so the combination may increase drowsiness. Valproate may also contribute to weight gain and metabolic effects alongside the antipsychotic.
How serious is the interaction between Brexpiprazole and Valproic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and metabolic changes such as weight, glucose and lipids. Counsel patients about driving until the response is known.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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