Drug interactions
Brexpiprazole + Voxelotor
Severity: Moderate
Brexpiprazole and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor inhibits CYP3A4 and may increase brexpiprazole exposure, leading to more sedation, akathisia and hypotension. The effect is likely moderate rather than strong.
What this interaction means in plain words
Brexpiprazole and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Voxelotor belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4-mediated metabolism of brexpiprazole by voxelotor.
What to do
Monitor for brexpiprazole adverse effects and lower the dose if tolerability problems develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Brexpiprazole with Voxelotor?
MediHelp rates the interaction as moderate. Brexpiprazole and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor inhibits CYP3A4 and may increase brexpiprazole exposure, leading to more sedation, akathisia and hypotension. The effect is likely moderate rather than strong.
How serious is the interaction between Brexpiprazole and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for brexpiprazole adverse effects and lower the dose if tolerability problems develop.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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