Drug interactions
Brexpiprazole + Ziprasidone
Severity: Major
Brexpiprazole and Ziprasidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are atypical antipsychotics, and using them together adds to sedation, extrapyramidal symptoms and orthostasis. Ziprasidone prolongs the QT interval, and the combination offers little proven benefit over monotherapy.
What this interaction means in plain words
Brexpiprazole and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Brexpiprazole belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive dopamine and serotonin receptor antagonism with overlapping sedative effects, plus QT prolongation from ziprasidone.
What to do
Avoid combining where possible. If used together, obtain a baseline ECG, correct potassium and magnesium, and monitor for sedation and extrapyramidal symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Brexpiprazole and Ziprasidone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Brexpiprazole
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Brexpiprazole with Ziprasidone?
MediHelp rates the interaction as major. Brexpiprazole and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are atypical antipsychotics, and using them together adds to sedation, extrapyramidal symptoms and orthostasis. Ziprasidone prolongs the QT interval, and the combination offers little proven benefit over monotherapy.
How serious is the interaction between Brexpiprazole and Ziprasidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible. If used together, obtain a baseline ECG, correct potassium and magnesium, and monitor for sedation and extrapyramidal symptoms.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
