Drug interactions
Brexucabtagene autoleucel + Teriflunomide
Severity: Moderate
Brexucabtagene autoleucel and Teriflunomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide is an immunomodulator that reduces proliferation of activated lymphocytes. Given around CAR T-cell therapy, it may blunt T-cell expansion and efficacy and add to infection risk in an already immunocompromised patient.
What this interaction means in plain words
Brexucabtagene autoleucel and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexucabtagene autoleucel belongs to Oncology; Teriflunomide belongs to Central Nervous System.
Why it happens
Additive immunosuppression via inhibition of pyrimidine synthesis in proliferating lymphocytes may impair CAR T-cell expansion and function.
What to do
Avoid teriflunomide around leukapheresis and CAR T infusion where possible and consider an alternative. If it was recently used, consider an accelerated elimination procedure and monitor for infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Teriflunomide
- Ifosfamide + Teriflunomide Major
- Lomustine + Teriflunomide Major
- Amiodarone + Teriflunomide Moderate
- Axicabtagene ciloleucel + Teriflunomide Moderate
- Ciltacabtagene autoleucel + Teriflunomide Moderate
- Clozapine + Teriflunomide Moderate
Other interactions of Brexucabtagene autoleucel
Frequently asked questions
Can I take Brexucabtagene autoleucel with Teriflunomide?
MediHelp rates the interaction as moderate. Brexucabtagene autoleucel and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teriflunomide is an immunomodulator that reduces proliferation of activated lymphocytes. Given around CAR T-cell therapy, it may blunt T-cell expansion and efficacy and add to infection risk in an already immunocompromised patient.
How serious is the interaction between Brexucabtagene autoleucel and Teriflunomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid teriflunomide around leukapheresis and CAR T infusion where possible and consider an alternative. If it was recently used, consider an accelerated elimination procedure and monitor for infection.
What other medicines interact with Teriflunomide?
MediHelp also lists interactions of Teriflunomide with, for example, Ifosfamide, Lomustine, Amiodarone. The full list is on the Teriflunomide page.
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