Drug interactions
Lomustine + Teriflunomide
Severity: Major
Lomustine and Teriflunomide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents impair immune function and lomustine causes delayed, prolonged myelosuppression. Combined use may increase the risk of serious infection and cytopenias. Teriflunomide's long half-life prolongs the overlap.
What this interaction means in plain words
Lomustine and Teriflunomide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lomustine belongs to Oncology; Teriflunomide belongs to Central Nervous System.
Why it happens
Additive immunosuppression and bone marrow suppression.
What to do
Avoid if possible; otherwise monitor full blood counts frequently, including for weeks after lomustine doses, and consider accelerated elimination of teriflunomide if toxicity occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Teriflunomide
- Ifosfamide + Teriflunomide Major
- Amiodarone + Teriflunomide Moderate
- Axicabtagene ciloleucel + Teriflunomide Moderate
- Brexucabtagene autoleucel + Teriflunomide Moderate
- Ciltacabtagene autoleucel + Teriflunomide Moderate
- Clozapine + Teriflunomide Moderate
Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Lomustine with Teriflunomide?
MediHelp rates the interaction as major. Lomustine and Teriflunomide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents impair immune function and lomustine causes delayed, prolonged myelosuppression. Combined use may increase the risk of serious infection and cytopenias. Teriflunomide's long half-life prolongs the overlap.
How serious is the interaction between Lomustine and Teriflunomide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor full blood counts frequently, including for weeks after lomustine doses, and consider accelerated elimination of teriflunomide if toxicity occurs.
What other medicines interact with Teriflunomide?
MediHelp also lists interactions of Teriflunomide with, for example, Ifosfamide, Amiodarone, Axicabtagene ciloleucel. The full list is on the Teriflunomide page.
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