Drug interactions
Amiodarone + Teriflunomide
Severity: Moderate
Amiodarone and Teriflunomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide may raise amiodarone exposure through CYP2C8 inhibition, and both drugs can cause liver toxicity and peripheral neuropathy. Combined use may increase the risk of these adverse effects.
What this interaction means in plain words
Amiodarone and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Teriflunomide belongs to Central Nervous System.
Why it happens
Teriflunomide inhibits CYP2C8, which contributes to the metabolism of amiodarone, along with overlapping hepatotoxic and neurotoxic effects.
What to do
Monitor liver enzymes and for neuropathy symptoms and amiodarone toxicity. Reassess the need for both agents if abnormalities develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amiodarone and Teriflunomide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Teriflunomide
Frequently asked questions
Can I take Amiodarone with Teriflunomide?
MediHelp rates the interaction as moderate. Amiodarone and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teriflunomide may raise amiodarone exposure through CYP2C8 inhibition, and both drugs can cause liver toxicity and peripheral neuropathy. Combined use may increase the risk of these adverse effects.
How serious is the interaction between Amiodarone and Teriflunomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and for neuropathy symptoms and amiodarone toxicity. Reassess the need for both agents if abnormalities develop.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
