Drug interactions
Ifosfamide + Teriflunomide
Severity: Major
Ifosfamide and Teriflunomide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress immune function and bone marrow, so combined use may raise the risk of infection and cytopenias. Ifosfamide is a cytotoxic agent and teriflunomide has a very long elimination half-life, so the effect persists after stopping.
What this interaction means in plain words
Ifosfamide and Teriflunomide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ifosfamide belongs to Oncology; Teriflunomide belongs to Central Nervous System.
Why it happens
Additive immunosuppressive and myelosuppressive effects.
What to do
Avoid combining where possible; if needed, monitor blood counts and signs of infection closely, and consider accelerated elimination of teriflunomide if toxicity develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Teriflunomide
- Lomustine + Teriflunomide Major
- Amiodarone + Teriflunomide Moderate
- Axicabtagene ciloleucel + Teriflunomide Moderate
- Brexucabtagene autoleucel + Teriflunomide Moderate
- Ciltacabtagene autoleucel + Teriflunomide Moderate
- Clozapine + Teriflunomide Moderate
Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Ifosfamide with Teriflunomide?
MediHelp rates the interaction as major. Ifosfamide and Teriflunomide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs suppress immune function and bone marrow, so combined use may raise the risk of infection and cytopenias. Ifosfamide is a cytotoxic agent and teriflunomide has a very long elimination half-life, so the effect persists after stopping.
How serious is the interaction between Ifosfamide and Teriflunomide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if needed, monitor blood counts and signs of infection closely, and consider accelerated elimination of teriflunomide if toxicity develops.
What other medicines interact with Teriflunomide?
MediHelp also lists interactions of Teriflunomide with, for example, Lomustine, Amiodarone, Axicabtagene ciloleucel. The full list is on the Teriflunomide page.
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