Drug interactions
Clozapine + Teriflunomide
Severity: Moderate
Clozapine and Teriflunomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide is a weak CYP1A2 inducer and may modestly lower clozapine concentrations. Both drugs can also cause neutropenia, which is important in clozapine treatment.
What this interaction means in plain words
Clozapine and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Teriflunomide belongs to Central Nervous System.
Why it happens
Weak induction of CYP1A2 by teriflunomide increases clozapine clearance, with additive hematologic toxicity.
What to do
Monitor clinical response and consider clozapine levels, and keep monitoring neutrophil counts closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clozapine and Teriflunomide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Teriflunomide
Frequently asked questions
Can I take Clozapine with Teriflunomide?
MediHelp rates the interaction as moderate. Clozapine and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teriflunomide is a weak CYP1A2 inducer and may modestly lower clozapine concentrations. Both drugs can also cause neutropenia, which is important in clozapine treatment.
How serious is the interaction between Clozapine and Teriflunomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and consider clozapine levels, and keep monitoring neutrophil counts closely.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
