Drug interactions
Brigatinib + Chloramphenicol
Severity: Moderate
Brigatinib and Chloramphenicol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brigatinib is cleared mainly by CYP3A4, so inhibition by chloramphenicol may raise its exposure and increase pulmonary, hepatic and other toxicity.
What this interaction means in plain words
Brigatinib and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brigatinib belongs to Oncology; Chloramphenicol belongs to Anti Bacterial.
Why it happens
Inhibition of CYP3A4-mediated metabolism of brigatinib.
What to do
Prefer an alternative antibiotic. If unavoidable, consider reducing the brigatinib dose per labeling for CYP3A inhibitors and monitor for respiratory symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Brigatinib
Frequently asked questions
Can I take Brigatinib with Chloramphenicol?
MediHelp rates the interaction as moderate. Brigatinib and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brigatinib is cleared mainly by CYP3A4, so inhibition by chloramphenicol may raise its exposure and increase pulmonary, hepatic and other toxicity.
How serious is the interaction between Brigatinib and Chloramphenicol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antibiotic. If unavoidable, consider reducing the brigatinib dose per labeling for CYP3A inhibitors and monitor for respiratory symptoms.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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