Drug interactions
Brigatinib + Imatinib
Severity: Moderate
Brigatinib and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib is a CYP3A4 inhibitor and may increase brigatinib concentrations. Higher exposure raises the risk of brigatinib adverse effects such as pulmonary toxicity, hypertension, bradycardia and pancreatic enzyme elevation.
What this interaction means in plain words
Brigatinib and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brigatinib belongs to Oncology; Imatinib belongs to Oncology.
Why it happens
Imatinib inhibits CYP3A4-mediated metabolism of brigatinib.
What to do
Prefer an alternative to imatinib where possible. If it is needed, reduce the brigatinib dose by about half and monitor for respiratory symptoms, heart rate and blood pressure; restore the earlier dose after imatinib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Brigatinib
Frequently asked questions
Can I take Brigatinib with Imatinib?
MediHelp rates the interaction as moderate. Brigatinib and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib is a CYP3A4 inhibitor and may increase brigatinib concentrations. Higher exposure raises the risk of brigatinib adverse effects such as pulmonary toxicity, hypertension, bradycardia and pancreatic enzyme elevation.
How serious is the interaction between Brigatinib and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative to imatinib where possible. If it is needed, reduce the brigatinib dose by about half and monitor for respiratory symptoms, heart rate and blood pressure; restore the earlier dose after imatinib is stopped.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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