Drug interactions
Brigatinib + Mifepristone
Severity: Major
Brigatinib and Mifepristone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone, a strong CYP3A4 inhibitor, can increase brigatinib exposure. This raises the risk of brigatinib toxicities such as pulmonary reactions, hypertension, bradycardia and pancreatic enzyme elevation.
What this interaction means in plain words
Brigatinib and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Brigatinib belongs to Oncology; Mifepristone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4-mediated brigatinib metabolism by mifepristone.
What to do
Prefer an alternative to mifepristone. If unavoidable, reduce the brigatinib dose by about half and resume the prior dose after mifepristone is stopped for an appropriate washout.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Brigatinib
Frequently asked questions
Can I take Brigatinib with Mifepristone?
MediHelp rates the interaction as major. Brigatinib and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone, a strong CYP3A4 inhibitor, can increase brigatinib exposure. This raises the risk of brigatinib toxicities such as pulmonary reactions, hypertension, bradycardia and pancreatic enzyme elevation.
How serious is the interaction between Brigatinib and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative to mifepristone. If unavoidable, reduce the brigatinib dose by about half and resume the prior dose after mifepristone is stopped for an appropriate washout.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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