Drug interactions
Brigatinib + Nicardipine
Severity: Moderate
Brigatinib and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine is a weaker CYP3A inhibitor than the strong inhibitors that prompt brigatinib dose changes. A modest increase in brigatinib exposure may occur, increasing risk of pulmonary, hypertensive and visual adverse effects.
What this interaction means in plain words
Brigatinib and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brigatinib belongs to Oncology; Nicardipine belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4 by nicardipine reduces brigatinib metabolism.
What to do
Monitor for respiratory symptoms, blood pressure and heart rate. Reduce the brigatinib dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Brigatinib
Frequently asked questions
Can I take Brigatinib with Nicardipine?
MediHelp rates the interaction as moderate. Brigatinib and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine is a weaker CYP3A inhibitor than the strong inhibitors that prompt brigatinib dose changes. A modest increase in brigatinib exposure may occur, increasing risk of pulmonary, hypertensive and visual adverse effects.
How serious is the interaction between Brigatinib and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for respiratory symptoms, blood pressure and heart rate. Reduce the brigatinib dose if toxicity develops.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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