Drug interactions
Brigatinib + Quinidine
Severity: Moderate
Brigatinib and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brigatinib may induce CYP3A4 and lower quinidine concentrations, risking loss of antiarrhythmic effect. Evidence is mainly from in vitro data.
What this interaction means in plain words
Brigatinib and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brigatinib belongs to Oncology; Quinidine belongs to Anti Parasitic.
Why it happens
Induction of CYP3A4 by brigatinib increases quinidine metabolism.
What to do
Monitor quinidine concentrations and ECG and adjust the dose as needed. Consider an alternative if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Brigatinib
Frequently asked questions
Can I take Brigatinib with Quinidine?
MediHelp rates the interaction as moderate. Brigatinib and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brigatinib may induce CYP3A4 and lower quinidine concentrations, risking loss of antiarrhythmic effect. Evidence is mainly from in vitro data.
How serious is the interaction between Brigatinib and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor quinidine concentrations and ECG and adjust the dose as needed. Consider an alternative if control is lost.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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