Drug interactions
Brimonidine + Mirtazapine
Severity: Minor
Brimonidine and Mirtazapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine is an alpha-2 agonist that can cause drowsiness when absorbed systemically, and mirtazapine is strongly sedating. Ophthalmic use gives low systemic exposure, so the additive effect is usually modest but may be noticeable in susceptible patients.
What this interaction means in plain words
Brimonidine and Mirtazapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brimonidine belongs to Miscellaneous; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive CNS depression; brimonidine central alpha-2 agonism plus mirtazapine H1 antagonism.
What to do
Ask about excessive daytime drowsiness after starting brimonidine drops. Advise caution with driving if sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Mirtazapine?
MediHelp rates the interaction as minor. Brimonidine and Mirtazapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brimonidine is an alpha-2 agonist that can cause drowsiness when absorbed systemically, and mirtazapine is strongly sedating. Ophthalmic use gives low systemic exposure, so the additive effect is usually modest but may be noticeable in susceptible patients.
How serious is the interaction between Brimonidine and Mirtazapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask about excessive daytime drowsiness after starting brimonidine drops. Advise caution with driving if sedation occurs.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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