Drug interactions
Brimonidine + Sevoflurane
Severity: Moderate
Brimonidine and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine is an alpha-2 agonist, and systemic absorption from ophthalmic use can cause drowsiness and hypotension. These effects may add to sevoflurane anesthesia, particularly in children, who are sensitive to brimonidine.
What this interaction means in plain words
Brimonidine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brimonidine belongs to Miscellaneous; Sevoflurane belongs to Central Nervous System.
Why it happens
Alpha-2 adrenergic agonism adds to CNS depression and hemodynamic depression from the volatile anesthetic.
What to do
Monitor blood pressure, heart rate and sedation depth. Be particularly vigilant in infants and young children receiving brimonidine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Sevoflurane?
MediHelp rates the interaction as moderate. Brimonidine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brimonidine is an alpha-2 agonist, and systemic absorption from ophthalmic use can cause drowsiness and hypotension. These effects may add to sevoflurane anesthesia, particularly in children, who are sensitive to brimonidine.
How serious is the interaction between Brimonidine and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and sedation depth. Be particularly vigilant in infants and young children receiving brimonidine.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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