Drug interactions
Brivaracetam + Perampanel
Severity: Moderate
Brivaracetam and Perampanel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both antiseizure drugs commonly cause somnolence, dizziness, and ataxia. Combined use may intensify these effects, and perampanel can also cause irritability and mood changes.
What this interaction means in plain words
Brivaracetam and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brivaracetam belongs to Central Nervous System; Perampanel belongs to Central Nervous System.
Why it happens
Additive CNS adverse effects from two antiseizure medications acting through different mechanisms.
What to do
Monitor for dizziness, gait disturbance, sedation, and behavioral changes when adding either drug. Titrate slowly and adjust doses according to tolerability and seizure control.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brivaracetam
Other interactions of Perampanel
- Apalutamide + Perampanel Major
- Enzalutamide + Perampanel Major
- Alprazolam + Perampanel Moderate
- Amisulpride + Perampanel Moderate
- Amobarbital + Perampanel Moderate
- Asenapine + Perampanel Moderate
Frequently asked questions
Can I take Brivaracetam with Perampanel?
MediHelp rates the interaction as moderate. Brivaracetam and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both antiseizure drugs commonly cause somnolence, dizziness, and ataxia. Combined use may intensify these effects, and perampanel can also cause irritability and mood changes.
How serious is the interaction between Brivaracetam and Perampanel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, gait disturbance, sedation, and behavioral changes when adding either drug. Titrate slowly and adjust doses according to tolerability and seizure control.
What other medicines interact with Brivaracetam?
MediHelp also lists interactions of Brivaracetam with, for example, Benzhydrocodone / acetaminophen, Sodium oxybate, Acetaminophen / phenyltoloxamine. The full list is on the Brivaracetam page.
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