Drug interactions
Brivaracetam + Pyrilamine
Severity: Minor
Brivaracetam and Pyrilamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pyrilamine is a first-generation antihistamine that causes drowsiness, and brivaracetam can add to this effect. Alertness and psychomotor performance may be reduced.
What this interaction means in plain words
Brivaracetam and Pyrilamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brivaracetam belongs to Central Nervous System; Pyrilamine belongs to Respiratory.
Why it happens
Additive CNS depression from H1 antihistamine action and brivaracetam.
What to do
Advise patients to watch for increased drowsiness and avoid driving if affected. Choose a non-sedating antihistamine if sedation is a problem.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Brivaracetam
Other interactions of Pyrilamine
- Fentanyl + Pyrilamine Moderate
- Levetiracetam + Pyrilamine Moderate
- Amisulpride + Pyrilamine Minor
- Asenapine + Pyrilamine Minor
- Brexpiprazole + Pyrilamine Minor
- Brimonidine + Pyrilamine Minor
Frequently asked questions
Can I take Brivaracetam with Pyrilamine?
MediHelp rates the interaction as minor. Brivaracetam and Pyrilamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pyrilamine is a first-generation antihistamine that causes drowsiness, and brivaracetam can add to this effect. Alertness and psychomotor performance may be reduced.
How serious is the interaction between Brivaracetam and Pyrilamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to watch for increased drowsiness and avoid driving if affected. Choose a non-sedating antihistamine if sedation is a problem.
What other medicines interact with Brivaracetam?
MediHelp also lists interactions of Brivaracetam with, for example, Benzhydrocodone / acetaminophen, Sodium oxybate, Acetaminophen / phenyltoloxamine. The full list is on the Brivaracetam page.
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