Drug interactions
Levetiracetam + Pyrilamine
Severity: Moderate
Levetiracetam and Pyrilamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pyrilamine is a first-generation antihistamine that commonly causes drowsiness. With levetiracetam, sedation and impaired alertness may be greater.
What this interaction means in plain words
Levetiracetam and Pyrilamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levetiracetam belongs to Central Nervous System; Pyrilamine belongs to Respiratory.
Why it happens
Additive central nervous system depression (pharmacodynamic).
What to do
Advise patients to avoid driving or hazardous tasks if drowsy, and consider a non-sedating antihistamine as an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levetiracetam
Other interactions of Pyrilamine
- Fentanyl + Pyrilamine Moderate
- Amisulpride + Pyrilamine Minor
- Asenapine + Pyrilamine Minor
- Brexpiprazole + Pyrilamine Minor
- Brimonidine + Pyrilamine Minor
- Brivaracetam + Pyrilamine Minor
Frequently asked questions
Can I take Levetiracetam with Pyrilamine?
MediHelp rates the interaction as moderate. Levetiracetam and Pyrilamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pyrilamine is a first-generation antihistamine that commonly causes drowsiness. With levetiracetam, sedation and impaired alertness may be greater.
How serious is the interaction between Levetiracetam and Pyrilamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid driving or hazardous tasks if drowsy, and consider a non-sedating antihistamine as an alternative.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
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