Drug interactions
Amisulpride + Pyrilamine
Severity: Minor
Amisulpride and Pyrilamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pyrilamine is a first-generation sedating antihistamine. With amisulpride, drowsiness and impaired alertness may be additive, and anticholinergic effects may also accumulate in susceptible patients.
What this interaction means in plain words
Amisulpride and Pyrilamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amisulpride belongs to Central Nervous System; Pyrilamine belongs to Respiratory.
Why it happens
Additive CNS depression via histamine H1 antagonism and amisulpride's sedative effects.
What to do
Advise patients about drowsiness and to avoid driving if affected. Consider a non-sedating antihistamine if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Other interactions of Pyrilamine
- Fentanyl + Pyrilamine Moderate
- Levetiracetam + Pyrilamine Moderate
- Asenapine + Pyrilamine Minor
- Brexpiprazole + Pyrilamine Minor
- Brimonidine + Pyrilamine Minor
- Brivaracetam + Pyrilamine Minor
Frequently asked questions
Can I take Amisulpride with Pyrilamine?
MediHelp rates the interaction as minor. Amisulpride and Pyrilamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pyrilamine is a first-generation sedating antihistamine. With amisulpride, drowsiness and impaired alertness may be additive, and anticholinergic effects may also accumulate in susceptible patients.
How serious is the interaction between Amisulpride and Pyrilamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients about drowsiness and to avoid driving if affected. Consider a non-sedating antihistamine if needed.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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