Drug interactions
Brexpiprazole + Pyrilamine
Severity: Minor
Brexpiprazole and Pyrilamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pyrilamine is a first-generation sedating antihistamine that may add to brexpiprazole-related drowsiness. Impaired alertness and psychomotor function can result.
What this interaction means in plain words
Brexpiprazole and Pyrilamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brexpiprazole belongs to Central Nervous System; Pyrilamine belongs to Respiratory.
Why it happens
Additive CNS depression through histamine H1 antagonism and antipsychotic sedation.
What to do
Counsel patients about drowsiness and advise avoiding driving if affected. Use a non-sedating antihistamine if appropriate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Brexpiprazole
Other interactions of Pyrilamine
- Fentanyl + Pyrilamine Moderate
- Levetiracetam + Pyrilamine Moderate
- Amisulpride + Pyrilamine Minor
- Asenapine + Pyrilamine Minor
- Brimonidine + Pyrilamine Minor
- Brivaracetam + Pyrilamine Minor
Frequently asked questions
Can I take Brexpiprazole with Pyrilamine?
MediHelp rates the interaction as minor. Brexpiprazole and Pyrilamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pyrilamine is a first-generation sedating antihistamine that may add to brexpiprazole-related drowsiness. Impaired alertness and psychomotor function can result.
How serious is the interaction between Brexpiprazole and Pyrilamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about drowsiness and advise avoiding driving if affected. Use a non-sedating antihistamine if appropriate.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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