Drug interactions
Asenapine + Pyrilamine
Severity: Minor
Asenapine and Pyrilamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pyrilamine is a sedating antihistamine and, combined with asenapine, may increase drowsiness and reduce psychomotor performance. Anticholinergic effects may also be additive.
What this interaction means in plain words
Asenapine and Pyrilamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Asenapine belongs to Central Nervous System; Pyrilamine belongs to Respiratory.
Why it happens
Additive CNS depression through histamine H1 antagonism and other sedative effects.
What to do
Advise patients about increased drowsiness and avoid driving until response is known. Consider a non-sedating antihistamine if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Pyrilamine
- Fentanyl + Pyrilamine Moderate
- Levetiracetam + Pyrilamine Moderate
- Amisulpride + Pyrilamine Minor
- Brexpiprazole + Pyrilamine Minor
- Brimonidine + Pyrilamine Minor
- Brivaracetam + Pyrilamine Minor
Frequently asked questions
Can I take Asenapine with Pyrilamine?
MediHelp rates the interaction as minor. Asenapine and Pyrilamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pyrilamine is a sedating antihistamine and, combined with asenapine, may increase drowsiness and reduce psychomotor performance. Anticholinergic effects may also be additive.
How serious is the interaction between Asenapine and Pyrilamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients about increased drowsiness and avoid driving until response is known. Consider a non-sedating antihistamine if needed.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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