Drug interactions
Fentanyl + Pyrilamine
Severity: Moderate
Fentanyl and Pyrilamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pyrilamine is a sedating first-generation antihistamine, and fentanyl is an opioid. Together they increase drowsiness and psychomotor impairment and may add to respiratory depression.
What this interaction means in plain words
Fentanyl and Pyrilamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fentanyl belongs to Musculoskeletal; Pyrilamine belongs to Respiratory.
Why it happens
Additive CNS depression through histamine H1 blockade and opioid receptor agonism.
What to do
Avoid unnecessary use of sedating antihistamines with opioids, or use lower doses and monitor sedation. Advise against driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Pyrilamine
- Levetiracetam + Pyrilamine Moderate
- Amisulpride + Pyrilamine Minor
- Asenapine + Pyrilamine Minor
- Brexpiprazole + Pyrilamine Minor
- Brimonidine + Pyrilamine Minor
- Brivaracetam + Pyrilamine Minor
Frequently asked questions
Can I take Fentanyl with Pyrilamine?
MediHelp rates the interaction as moderate. Fentanyl and Pyrilamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pyrilamine is a sedating first-generation antihistamine, and fentanyl is an opioid. Together they increase drowsiness and psychomotor impairment and may add to respiratory depression.
How serious is the interaction between Fentanyl and Pyrilamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary use of sedating antihistamines with opioids, or use lower doses and monitor sedation. Advise against driving and alcohol.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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