Drug interactions
Brodalumab + Quinidine
Severity: Minor
Brodalumab and Quinidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chronic inflammation suppresses CYP450 enzyme expression, and treating the inflammation with brodalumab may restore enzyme activity. This could slightly lower exposure to CYP substrates such as quinidine. The effect is theoretical and the clinical impact is probably small.
What this interaction means in plain words
Brodalumab and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brodalumab belongs to Miscellaneous; Quinidine belongs to Anti Parasitic.
Why it happens
Normalization of cytokine-suppressed CYP450 expression after IL-17 receptor blockade may increase metabolism of CYP substrates.
What to do
When starting or stopping brodalumab, monitor quinidine plasma levels or ECG response if clinically indicated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Brodalumab
- Brodalumab + Upadacitinib Major
- Brodalumab + Warfarin Moderate
- Brodalumab + Carbamazepine Minor
- Brodalumab + Clonidine Minor
- Brodalumab + Cyclosporin Minor
- Brodalumab + Phenytoin Minor
Frequently asked questions
Can I take Brodalumab with Quinidine?
MediHelp rates the interaction as minor. Brodalumab and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chronic inflammation suppresses CYP450 enzyme expression, and treating the inflammation with brodalumab may restore enzyme activity. This could slightly lower exposure to CYP substrates such as quinidine. The effect is theoretical and the clinical impact is probably small.
How serious is the interaction between Brodalumab and Quinidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: When starting or stopping brodalumab, monitor quinidine plasma levels or ECG response if clinically indicated.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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