Drug interactions
Brodalumab + Valproic acid
Severity: Minor
Brodalumab and Valproic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chronic inflammation can suppress CYP enzyme expression, and an anti-IL-17 receptor antibody may reverse this effect. This is theoretical, and a meaningful change in valproate exposure has not been established.
What this interaction means in plain words
Brodalumab and Valproic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brodalumab belongs to Miscellaneous; Valproic acid belongs to Central Nervous System.
Why it happens
Possible normalization of cytokine-suppressed CYP450 activity after IL-17 receptor blockade; not established for valproate.
What to do
No routine adjustment is needed. Consider checking valproate levels or clinical response if seizure control or mood changes after starting or stopping brodalumab.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Valproic acid
- Ertapenem + Valproic acid Contraindicated
- Imipenem / cilastatin / relebactam + Valproic acid Contraindicated
- Imipenem / cilastatin + Valproic acid Contraindicated
- Meropenem / vaborbactam + Valproic acid Contraindicated
- Meropenem + Valproic acid Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Major
Other interactions of Brodalumab
- Brodalumab + Upadacitinib Major
- Brodalumab + Warfarin Moderate
- Brodalumab + Carbamazepine Minor
- Brodalumab + Clonidine Minor
- Brodalumab + Cyclosporin Minor
- Brodalumab + Phenytoin Minor
Frequently asked questions
Can I take Brodalumab with Valproic acid?
MediHelp rates the interaction as minor. Brodalumab and Valproic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chronic inflammation can suppress CYP enzyme expression, and an anti-IL-17 receptor antibody may reverse this effect. This is theoretical, and a meaningful change in valproate exposure has not been established.
How serious is the interaction between Brodalumab and Valproic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Consider checking valproate levels or clinical response if seizure control or mood changes after starting or stopping brodalumab.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Imipenem / cilastatin. The full list is on the Valproic acid page.
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