Drug interactions
Bromocriptine + Captopril-hydrochlorothiazide
Severity: Moderate
Bromocriptine and Captopril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bromocriptine can cause orthostatic hypotension, particularly at initiation, and may add to the effect of antihypertensives. Dizziness and syncope are possible.
What this interaction means in plain words
Bromocriptine and Captopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bromocriptine belongs to Central Nervous System; Captopril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive hypotension from dopamine agonist vascular effects with ACE inhibition and diuresis.
What to do
Monitor blood pressure during bromocriptine initiation and dose increases. Advise slow position changes and reduce antihypertensives if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Bromocriptine
Frequently asked questions
Can I take Bromocriptine with Captopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Bromocriptine and Captopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bromocriptine can cause orthostatic hypotension, particularly at initiation, and may add to the effect of antihypertensives. Dizziness and syncope are possible.
How serious is the interaction between Bromocriptine and Captopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during bromocriptine initiation and dose increases. Advise slow position changes and reduce antihypertensives if needed.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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