Drug interactions
Bromocriptine + Lenacapavir
Severity: Moderate
Bromocriptine and Lenacapavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor, and its effect persists for months after subcutaneous dosing. Bromocriptine levels may increase, raising the risk of nausea, hypotension, somnolence and other dopaminergic effects.
What this interaction means in plain words
Bromocriptine and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bromocriptine belongs to Central Nervous System; Lenacapavir belongs to Anti Virals.
Why it happens
Lenacapavir inhibits CYP3A4, decreasing the metabolism of bromocriptine.
What to do
Monitor blood pressure and dopaminergic adverse effects, and lower the bromocriptine dose if they occur. Keep the long inhibitory tail of lenacapavir in mind when starting bromocriptine later.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bromocriptine
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Bromocriptine with Lenacapavir?
MediHelp rates the interaction as moderate. Bromocriptine and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A inhibitor, and its effect persists for months after subcutaneous dosing. Bromocriptine levels may increase, raising the risk of nausea, hypotension, somnolence and other dopaminergic effects.
How serious is the interaction between Bromocriptine and Lenacapavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and dopaminergic adverse effects, and lower the bromocriptine dose if they occur. Keep the long inhibitory tail of lenacapavir in mind when starting bromocriptine later.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
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