Drug interactions
Bromocriptine + Levodopa
Severity: Moderate
Bromocriptine and Levodopa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs enhance dopaminergic stimulation, which is often used therapeutically in Parkinson disease. Together they can increase dyskinesia, nausea, hallucinations, orthostatic hypotension and impulse control problems.
What this interaction means in plain words
Bromocriptine and Levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bromocriptine belongs to Central Nervous System; Levodopa belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic dopaminergic stimulation, via a dopamine precursor and a direct D2 agonist.
What to do
Titrate both drugs slowly and reduce the levodopa dose if dyskinesia or psychiatric effects emerge. Monitor blood pressure and behavior.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bromocriptine
Other interactions of Levodopa
- Isocarboxazid + Levodopa Contraindicated
- Levodopa + Phenelzine Contraindicated
- Levodopa + Phenelzine (nonselective MAOI) Contraindicated
- Levodopa + Procarbazine Contraindicated
- Levodopa + Tranylcypromine Contraindicated
- Amisulpride + Levodopa Major
Frequently asked questions
Can I take Bromocriptine with Levodopa?
MediHelp rates the interaction as moderate. Bromocriptine and Levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs enhance dopaminergic stimulation, which is often used therapeutically in Parkinson disease. Together they can increase dyskinesia, nausea, hallucinations, orthostatic hypotension and impulse control problems.
How serious is the interaction between Bromocriptine and Levodopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate both drugs slowly and reduce the levodopa dose if dyskinesia or psychiatric effects emerge. Monitor blood pressure and behavior.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
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