Drug interactions
Bromocriptine + Mifepristone
Severity: Major
Bromocriptine and Mifepristone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and can raise bromocriptine exposure. Higher levels may cause nausea, hypotension, dizziness, syncope and other dopaminergic adverse effects.
What this interaction means in plain words
Bromocriptine and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bromocriptine belongs to Central Nervous System; Mifepristone belongs to Endocrine.
Why it happens
Mifepristone inhibits CYP3A4-mediated metabolism of bromocriptine, increasing its systemic concentrations.
What to do
Avoid the combination where possible, or start bromocriptine at a reduced dose and monitor blood pressure and dopaminergic adverse effects. Consider an alternative dopamine agonist not dependent on CYP3A4.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Bromocriptine
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Bromocriptine with Mifepristone?
MediHelp rates the interaction as major. Bromocriptine and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone inhibits CYP3A4 and can raise bromocriptine exposure. Higher levels may cause nausea, hypotension, dizziness, syncope and other dopaminergic adverse effects.
How serious is the interaction between Bromocriptine and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or start bromocriptine at a reduced dose and monitor blood pressure and dopaminergic adverse effects. Consider an alternative dopamine agonist not dependent on CYP3A4.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
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