Drug interactions
Bromocriptine + Mitotane
Severity: Moderate
Bromocriptine and Mitotane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane strongly induces CYP3A4 and can substantially lower bromocriptine concentrations. This may lead to loss of prolactin or growth hormone control or reduced antiparkinsonian effect, and the induction persists for weeks after mitotane is stopped.
What this interaction means in plain words
Bromocriptine and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bromocriptine belongs to Central Nervous System; Mitotane belongs to Oncology.
Why it happens
Mitotane induces CYP3A4, increasing the metabolic clearance of bromocriptine.
What to do
Monitor prolactin or clinical response and increase the bromocriptine dose if needed. Reduce the dose again after mitotane is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bromocriptine
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Bromocriptine with Mitotane?
MediHelp rates the interaction as moderate. Bromocriptine and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane strongly induces CYP3A4 and can substantially lower bromocriptine concentrations. This may lead to loss of prolactin or growth hormone control or reduced antiparkinsonian effect, and the induction persists for weeks after mitotane is stopped.
How serious is the interaction between Bromocriptine and Mitotane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor prolactin or clinical response and increase the bromocriptine dose if needed. Reduce the dose again after mitotane is discontinued.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
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