Drug interactions
Bromocriptine + Quetiapine
Severity: Moderate
Bromocriptine and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine blocks dopamine D2 receptors, though weakly, and may oppose the effect of bromocriptine. This is a lesser concern than with other antipsychotics, but bromocriptine may also worsen psychosis.
What this interaction means in plain words
Bromocriptine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bromocriptine belongs to Central Nervous System; Quetiapine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at dopamine D2 receptors.
What to do
Monitor motor symptoms or prolactin response and psychiatric status. Use the lowest effective quetiapine dose, as it is a preferred antipsychotic in Parkinson disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Bromocriptine
Frequently asked questions
Can I take Bromocriptine with Quetiapine?
MediHelp rates the interaction as moderate. Bromocriptine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine blocks dopamine D2 receptors, though weakly, and may oppose the effect of bromocriptine. This is a lesser concern than with other antipsychotics, but bromocriptine may also worsen psychosis.
How serious is the interaction between Bromocriptine and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor motor symptoms or prolactin response and psychiatric status. Use the lowest effective quetiapine dose, as it is a preferred antipsychotic in Parkinson disease.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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