Drug interactions
Bromocriptine + Secobarbital
Severity: Moderate
Bromocriptine and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bromocriptine is extensively metabolized by CYP3A4. Barbiturate induction may reduce its plasma concentrations and weaken control of prolactinoma, acromegaly or parkinsonian symptoms.
What this interaction means in plain words
Bromocriptine and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bromocriptine belongs to Central Nervous System; Secobarbital belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by secobarbital increases bromocriptine metabolism.
What to do
Monitor symptom control or prolactin levels and titrate bromocriptine upward if effect is lost. Reassess the dose if the barbiturate is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Bromocriptine
Frequently asked questions
Can I take Bromocriptine with Secobarbital?
MediHelp rates the interaction as moderate. Bromocriptine and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bromocriptine is extensively metabolized by CYP3A4. Barbiturate induction may reduce its plasma concentrations and weaken control of prolactinoma, acromegaly or parkinsonian symptoms.
How serious is the interaction between Bromocriptine and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control or prolactin levels and titrate bromocriptine upward if effect is lost. Reassess the dose if the barbiturate is withdrawn.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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