Drug interactions
Bromocriptine + Thioridazine
Severity: Major
Bromocriptine and Thioridazine: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bromocriptine is a dopamine agonist and thioridazine is a dopamine antagonist, so each opposes the other's effects. Thioridazine can reduce bromocriptine's benefit in Parkinson's disease, hyperprolactinemia or acromegaly, while bromocriptine may worsen psychosis.
What this interaction means in plain words
Bromocriptine and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bromocriptine belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at dopamine D2 receptors.
What to do
Avoid the combination when possible; use an antipsychotic with less D2 blockade such as quetiapine or clozapine in Parkinson's disease. Monitor prolactin or symptom control and psychiatric status if both are required.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Bromocriptine
Frequently asked questions
Can I take Bromocriptine with Thioridazine?
MediHelp rates the interaction as major. Bromocriptine and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bromocriptine is a dopamine agonist and thioridazine is a dopamine antagonist, so each opposes the other's effects. Thioridazine can reduce bromocriptine's benefit in Parkinson's disease, hyperprolactinemia or acromegaly, while bromocriptine may worsen psychosis.
How serious is the interaction between Bromocriptine and Thioridazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible; use an antipsychotic with less D2 blockade such as quetiapine or clozapine in Parkinson's disease. Monitor prolactin or symptom control and psychiatric status if both are required.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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