Drug interactions
Bromocriptine + Voxelotor
Severity: Moderate
Bromocriptine and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor can raise exposure to sensitive CYP3A4 substrates, and bromocriptine is cleared mainly by CYP3A4. Higher bromocriptine levels may increase dopaminergic adverse effects such as nausea, orthostatic hypotension, dizziness and somnolence.
What this interaction means in plain words
Bromocriptine and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bromocriptine belongs to Central Nervous System; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor inhibits CYP3A4 (hepatic and intestinal), reducing first-pass and systemic clearance of bromocriptine.
What to do
Start with a lower bromocriptine dose or reduce the dose if the combination is needed, and monitor blood pressure and dopaminergic adverse effects. Consider an alternative if effects are not tolerated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bromocriptine
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Bromocriptine with Voxelotor?
MediHelp rates the interaction as moderate. Bromocriptine and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor can raise exposure to sensitive CYP3A4 substrates, and bromocriptine is cleared mainly by CYP3A4. Higher bromocriptine levels may increase dopaminergic adverse effects such as nausea, orthostatic hypotension, dizziness and somnolence.
How serious is the interaction between Bromocriptine and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a lower bromocriptine dose or reduce the dose if the combination is needed, and monitor blood pressure and dopaminergic adverse effects. Consider an alternative if effects are not tolerated.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
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