Drug interactions
Bromocriptine + Ziprasidone
Severity: Moderate
Bromocriptine and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone blocks dopamine D2 receptors, which directly opposes the effect of bromocriptine. This can reduce control of parkinsonism, hyperprolactinemia or acromegaly and may worsen motor symptoms.
What this interaction means in plain words
Bromocriptine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bromocriptine belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between a D2 receptor antagonist and a D2 receptor agonist.
What to do
Avoid where possible; in Parkinson disease with psychosis, use quetiapine or clozapine instead. If both are essential, monitor symptom control and prolactin and adjust doses accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Bromocriptine
Frequently asked questions
Can I take Bromocriptine with Ziprasidone?
MediHelp rates the interaction as moderate. Bromocriptine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziprasidone blocks dopamine D2 receptors, which directly opposes the effect of bromocriptine. This can reduce control of parkinsonism, hyperprolactinemia or acromegaly and may worsen motor symptoms.
How serious is the interaction between Bromocriptine and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid where possible; in Parkinson disease with psychosis, use quetiapine or clozapine instead. If both are essential, monitor symptom control and prolactin and adjust doses accordingly.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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