Drug interactions
Brompheniramine + Clobazam
Severity: Moderate
Brompheniramine and Clobazam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam is a benzodiazepine, and adding a sedating antihistamine increases drowsiness, dizziness and psychomotor impairment. Respiratory depression is possible in susceptible patients.
What this interaction means in plain words
Brompheniramine and Clobazam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Clobazam belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A enhancement and H1 blockade.
What to do
Monitor sedation and respiratory status, and avoid alcohol. Use a non-sedating antihistamine when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Brompheniramine with Clobazam?
MediHelp rates the interaction as moderate. Brompheniramine and Clobazam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clobazam is a benzodiazepine, and adding a sedating antihistamine increases drowsiness, dizziness and psychomotor impairment. Respiratory depression is possible in susceptible patients.
How serious is the interaction between Brompheniramine and Clobazam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status, and avoid alcohol. Use a non-sedating antihistamine when possible.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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