Drug interactions
Brompheniramine + Clorazepate
Severity: Moderate
Brompheniramine and Clorazepate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brompheniramine is a first-generation sedating antihistamine, and combined with clorazepate it can cause marked drowsiness and reduced psychomotor performance. Older adults are at particular risk of confusion and falls.
What this interaction means in plain words
Brompheniramine and Clorazepate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Clorazepate belongs to Central Nervous System.
Why it happens
Additive CNS depression from central H1 antagonism and benzodiazepine GABA-A potentiation.
What to do
Avoid or limit sedating antihistamines in patients taking clorazepate, or choose a non-sedating antihistamine. Counsel about driving and avoid alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Brompheniramine and Clorazepate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Clorazepate?
MediHelp rates the interaction as moderate. Brompheniramine and Clorazepate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brompheniramine is a first-generation sedating antihistamine, and combined with clorazepate it can cause marked drowsiness and reduced psychomotor performance. Older adults are at particular risk of confusion and falls.
How serious is the interaction between Brompheniramine and Clorazepate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid or limit sedating antihistamines in patients taking clorazepate, or choose a non-sedating antihistamine. Counsel about driving and avoid alcohol.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
