Drug interactions
Brompheniramine + Desflurane
Severity: Moderate
Brompheniramine and Desflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brompheniramine is a sedating first-generation antihistamine that adds to CNS depression from general anesthetics. This may prolong recovery and increase drowsiness.
What this interaction means in plain words
Brompheniramine and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Desflurane belongs to Central Nervous System.
Why it happens
Additive CNS depression from H1 antagonism with anesthetic action.
What to do
Titrate desflurane to depth monitoring and observe for prolonged postoperative sedation and anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Desflurane?
MediHelp rates the interaction as moderate. Brompheniramine and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brompheniramine is a sedating first-generation antihistamine that adds to CNS depression from general anesthetics. This may prolong recovery and increase drowsiness.
How serious is the interaction between Brompheniramine and Desflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate desflurane to depth monitoring and observe for prolonged postoperative sedation and anticholinergic effects.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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