Drug interactions
Brompheniramine + Dexchlorpheniramine
Severity: Moderate
Brompheniramine and Dexchlorpheniramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are first-generation alkylamine antihistamines, so combining them duplicates therapy and adds sedation and anticholinergic effects without added benefit. Overdose-type effects such as confusion, dry mouth and urinary retention are more likely.
What this interaction means in plain words
Brompheniramine and Dexchlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Dexchlorpheniramine belongs to Respiratory.
Why it happens
Additive H1 antagonism and anticholinergic effects.
What to do
Avoid using both and keep to a single antihistamine. Review combination cold remedies for hidden duplication.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Other interactions of Dexchlorpheniramine
- Alprazolam + Dexchlorpheniramine Moderate
- Amisulpride + Dexchlorpheniramine Moderate
- Amitriptyline + Dexchlorpheniramine Moderate
- Amobarbital + Dexchlorpheniramine Moderate
- Asenapine + Dexchlorpheniramine Moderate
- Azelastine-fluticasone + Dexchlorpheniramine Moderate
Frequently asked questions
Can I take Brompheniramine with Dexchlorpheniramine?
MediHelp rates the interaction as moderate. Brompheniramine and Dexchlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are first-generation alkylamine antihistamines, so combining them duplicates therapy and adds sedation and anticholinergic effects without added benefit. Overdose-type effects such as confusion, dry mouth and urinary retention are more likely.
How serious is the interaction between Brompheniramine and Dexchlorpheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using both and keep to a single antihistamine. Review combination cold remedies for hidden duplication.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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