Drug interactions
Brompheniramine + Difelikefalin
Severity: Moderate
Brompheniramine and Difelikefalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin can cause dizziness, somnolence and fatigue, and a sedating antihistamine may add to these effects. Impaired alertness and falls are possible, particularly in dialysis patients.
What this interaction means in plain words
Brompheniramine and Difelikefalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Difelikefalin belongs to Dermatology.
Why it happens
Additive CNS depression from kappa-opioid agonism and H1 blockade.
What to do
Monitor for drowsiness and fall risk. Prefer a non-sedating antihistamine for pruritus or allergy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
Frequently asked questions
Can I take Brompheniramine with Difelikefalin?
MediHelp rates the interaction as moderate. Brompheniramine and Difelikefalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difelikefalin can cause dizziness, somnolence and fatigue, and a sedating antihistamine may add to these effects. Impaired alertness and falls are possible, particularly in dialysis patients.
How serious is the interaction between Brompheniramine and Difelikefalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for drowsiness and fall risk. Prefer a non-sedating antihistamine for pruritus or allergy.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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