Drug interactions
Brompheniramine + Eluxadoline
Severity: Moderate
Brompheniramine and Eluxadoline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline can cause constipation and, rarely, pancreatitis or sphincter of Oddi spasm. Anticholinergic antihistamines slow gut motility and may increase the risk of severe constipation.
What this interaction means in plain words
Brompheniramine and Eluxadoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Eluxadoline belongs to Gastrointestinal Tract.
Why it happens
Additive reduction of gastrointestinal motility via opioid receptor agonism and anticholinergic activity.
What to do
Monitor bowel function and stop the antihistamine or eluxadoline if severe constipation develops. Prefer a non-anticholinergic antihistamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Other interactions of Eluxadoline
Frequently asked questions
Can I take Brompheniramine with Eluxadoline?
MediHelp rates the interaction as moderate. Brompheniramine and Eluxadoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eluxadoline can cause constipation and, rarely, pancreatitis or sphincter of Oddi spasm. Anticholinergic antihistamines slow gut motility and may increase the risk of severe constipation.
How serious is the interaction between Brompheniramine and Eluxadoline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel function and stop the antihistamine or eluxadoline if severe constipation develops. Prefer a non-anticholinergic antihistamine.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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