Drug interactions
Brompheniramine + Ephedrine
Severity: Minor
Brompheniramine and Ephedrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brompheniramine causes drowsiness while ephedrine is a stimulant, so each may partly offset the other's CNS effect. The net result is unpredictable. Stimulant effects such as tachycardia, insomnia or raised blood pressure may still occur.
What this interaction means in plain words
Brompheniramine and Ephedrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brompheniramine belongs to Respiratory; Ephedrine belongs to Cardiovascular.
Why it happens
Opposing CNS effects of H1 antagonism and sympathomimetic stimulation; no established pharmacokinetic interaction.
What to do
No routine change is needed. Monitor blood pressure and heart rate in patients with cardiovascular disease, and do not rely on ephedrine to counteract sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Brompheniramine
Other interactions of Ephedrine
- Ephedrine + Isocarboxazid Contraindicated
- Ephedrine + Phenelzine Contraindicated
- Ephedrine + Procarbazine Contraindicated
- Ephedrine + Rasagiline Contraindicated
- Ephedrine + Selegiline Contraindicated
- Ephedrine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Brompheniramine with Ephedrine?
MediHelp rates the interaction as minor. Brompheniramine and Ephedrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brompheniramine causes drowsiness while ephedrine is a stimulant, so each may partly offset the other's CNS effect. The net result is unpredictable. Stimulant effects such as tachycardia, insomnia or raised blood pressure may still occur.
How serious is the interaction between Brompheniramine and Ephedrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Monitor blood pressure and heart rate in patients with cardiovascular disease, and do not rely on ephedrine to counteract sedation.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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