Drug interactions
Brompheniramine + Hydromorphone
Severity: Moderate
Brompheniramine and Hydromorphone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brompheniramine is a sedating antihistamine that can add to the drowsiness and psychomotor impairment caused by hydromorphone. Anticholinergic effects may also be increased.
What this interaction means in plain words
Brompheniramine and Hydromorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Hydromorphone belongs to Musculoskeletal.
Why it happens
Additive CNS depression from opioid receptor agonism and H1-antihistamine sedation.
What to do
Advise patients to avoid driving and alcohol and consider a non-sedating antihistamine. Monitor sedation in older or frail patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Hydromorphone?
MediHelp rates the interaction as moderate. Brompheniramine and Hydromorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brompheniramine is a sedating antihistamine that can add to the drowsiness and psychomotor impairment caused by hydromorphone. Anticholinergic effects may also be increased.
How serious is the interaction between Brompheniramine and Hydromorphone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid driving and alcohol and consider a non-sedating antihistamine. Monitor sedation in older or frail patients.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
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